Leptin target for obesity drugs comes into focus

Leptin target for obesity drugs comes into focus

Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain. Leptin is a hormone secreted by fat tissue that has been of interest for researchers in obesity and Type 2 diabetes since it was discovered in 1995.

Severely obese are fastest growing overweight Americans

Severely obese are fastest growing overweight Americans

The proportion of Americans who are severely obese — those people 100 pounds or more overweight — continues to increase rapidly and much faster than those with moderate obesity, but the rate of growth has slowed, according to a new RAND Corporation study. The RAND study found that from 2000 to 2010, the proportion of

Possibility of treating obesity with vaccination

Possibility of treating obesity with vaccination

New vaccines promote weight loss. A new study, published in Journal of Animal Science and Biotechnology, assesses the effectiveness of two somatostatin vaccinations, JH17 and JH18, in reducing weight gain and increasing weight loss in mice.

Obesity and obesity-related disease is a growing health issue worldwide. Somatostatin, a peptide hormone, inhibits the action of growth hormone (GH) and insulin-like growth factor (IGF-1), both of which increase metabolism and result in weight loss.

Obesity induced insulin sensitivity can be improved

Obesity induced insulin sensitivity can be improved

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance.

In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into other tissues.

Obesity is a major factor that contributes to insulin resistance, which can eventually lead to type 2 diabetes.

Excess weight during pregnancy may have health implications for offspring

Excess weight during pregnancy may have health implications for offspring

That overweight during pregnancy can lead to overweight children and adolescents has been known for some time, but new research at the Hebrew University of Jerusalem and in the US indicates that excess weight before and during pregnancy can have long-lasting health consequences for the offspring of such mothers even later in life.

Investigators at the Hebrew University-Hadassah Braun School of Public Health and Community Medicine and the Departments of Medicine and Epidemiology at the University of Washington, Seattle, have found a direct correlation between this maternal overweight and higher tendencies in their adult children towards overweight and other life-risking factors, such as high blood pressure and excess sugar and fat levels in the blood.

20% fat tax on unhealthy food & drinks and subsidies on healthy foods

20% fat tax on unhealthy food & drinks and subsidies on healthy foods

As an increasing number of countries introduce taxes on unhealthy food and drinks, Oliver Mytton and colleagues at the University of Oxford examine the evidence on the health effects of food taxes.

Taxes on unhealthy food and drinks would need to be at least 20% to have a significant effect on diet-related conditions such as obesity and heart disease. Ideally, this should be combined with subsidies on healthy foods such as fruit and vegetables.

Obesity epidemic in America underestimated

Obesity epidemic in America underestimated

The scope of the obesity epidemic in the United States has been greatly underestimated, according to a study published Apr. 2 in the journal PLoS ONE.

Researchers found that the Body Mass Index (BMI) substantially under-diagnoses obesity when compared to the Dual Energy X-ray Absorptiometry (DXA) scan, a direct simultaneous measure of body fat, muscle mass, and bone density.

Dieting mothers increase obesity and diabetes risks in babies

Dieting mothers increase obesity and diabetes risks in babies

If you’re expecting, this might make you feel a little better about reaching for that pint of ice cream: New research published in the FASEB Journal suggests that twins, and babies of mothers who diet around the time of conception and in early pregnancy, may have an increased risk of obesity and type 2 diabetes throughout their lives.

This study provides exciting insights into how behavior can lead to epigenetic changes in offspring related to obesity and disease.

Gene in fat cells protects from type 2 diabetes

Gene in fat cells protects from type 2 diabetes

In a finding that may challenge popular notions of body fat and health, researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown how fat cells can protect the body against diabetes.

The results may lead to a new therapeutic strategy for preventing and treating type 2 diabetes and obesity-related metabolic diseases, the authors say.

Most weight loss supplements are not effective

Most weight loss supplements are not effective

An Oregon State University researcher has reviewed the body of evidence around weight loss supplements and has bad news for those trying to find a magic pill to lose weight and keep it off – it doesn’t exist. Do you know whether your weight loss supplement is effective?

Melinda Manore reviewed the evidence surrounding hundreds of weight loss supplements, a $2.4 billion industry in the United States, and said no research evidence exists that any single product results in significant weight loss – and many have detrimental health benefits.